Alimta Pemetrexed is an anti-cancer chemotherapy drug, available in the trade name of Alimta Tis medication is used in the treatment of malignant mesothelioma, as well as the treatment of non-small cell lung cancer after prior chemotherapy.
Mechanism of action:
Alimta Pemetrexed 500 Mg is chemically similar to folic acid and is in the class of chemotherapy drugs called folate antimetabolites
It works by inhibiting three enzymes used in purine and pyrimidine synthesisâthymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT)
By inhibiting the formation of precursor purine and pyrimidine nucleotides, pemetrexed prevents the formation of DNA and RNA, which are required for the growth and survival of both normal cells and cancer cells
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